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Retatrutide has not yet been studied in a dedicated sleep apnea trial, but given its greater weight loss, the expectation is that sleep apnea improvements would be at least as significant as those seen with tirzepatide, possibly more so

There have been reports of adverse effects on the kidneys with semaglutide use including acute kidney injury and worsening of chronic renal failure which may require hemodialysis

The side effect profiles differ somewhat , with tirzepatide showing similar GI effects but potentially different patterns of onset and resolution

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